Bioperine Black Pepper Benefits- Is It Beneficial?

Bioperine is black pepper extract. Black pepper, a flowering vine, belongs to the family Piperaceae and is grown for its peppercorn fruit. It has long been known as the king of spices and is the staple seasoning of several households worldwide.

Piperine, a compound present in black pepper, gives it a unique taste. Peperine compound is associated with several health benefits.

While most people enjoy only one or two touches of black pepper with each meal, many choose bioperine supplements to increase their consumption.

BioPerine is a patent for piperine extract that contains at least 95% piperine in a form that is well absorbed by the body. Perine is found in many supplements, alone or combined with other ingredients such as turmeric.


What is Bioperine Black Pepper?

Bioperine is a standardized extract of Black pepper. It is made by drying black piper and possesses at least 95% pepper.

Bioperine works as a thermo nutrient, which helps to increase nutrient absorption and bioavailability of nutrients. [1]

Black pepper bioperine can be co-administered with different nutrients to increase its bioavailability in humans and animals.

Bioperine Black Pepper Benefits

There are several bioperine black pepper benefits for health. Let’s take a look at the benefits of bioperine.

May Enhance Brain Function

An animal study showed that piperine significantly improved memory impairment and neurodegeneration. [2]

The reason for this action may be related in part to lipid peroxidation and depletion of acetylcholinesterase enzymes. [3] 

A study on rats found that piperine enhances memory and repair myelin sheath damage. Myelin sheath is an insulating cover around the nerve fibers in the brain and spinal cord. [4]

Thus, piperidine may provide potential treatment in people with multiple sclerosis.

Bioperine can help promote human mental health by enhancing the production of vital mood-related neurotransmitters. 

Together with curcumin, it can improve the production of neurotransmitters such as dopamine and serotonin.

However, keep in mind that the study was performed on animals. Therefore, human studies are needed to confirm whether piperine will have the same effect on humans.

May Enhance Nutrient Absorption

Co-administration of piperine with vitamins and minerals enhances its absorption. [5]

Study shows that black pepper co-administrated with iron to physically active, healthy individuals can increase iron absorption due to its bioavailability properties. [6]

Three studies on iron with black pepper show improvement in variables related to iron metabolism without harmful effects. [7]

In addition, research shows that absorption of carotenoids increases with piperine. Carotenoids are beneficial plant compounds. Carotenoids are known to strengthen the immune system and work as an antioxidant that prevents cell damage in the body. [8]

More research is needed; this could be a step forward in oral iron supplementation in physically active persons.

Also Read: Coconut Water in Diabetes

May Help Fight Inflammation

There are anti-inflammatory, anti-nociceptive, and anti-arthritic effects in piperine. [9]

Bioperine black pepper has many health benefits and several pharmacological effects, particularly against chronic diseases like decreased insulin resistance, anti-inflammatory effect, and enhancement of fatty liver. [10] 

Inflammation is a normal response from the immune system. It helps the body to protect against disease and infection.

In contrast, chronic inflammation can significantly damage your health in the long run. It can even contribute to some health conditions, such as cancer, heart disease, and diabetes [11]

Piperine is known to have anti-inflammatory activity. A study shows that piperine impede the production of many markers of inflammation in the brain [12]

Study results suggest that piperine may be a promising component in treating neurodegenerative illness. [13]

However, further research is needed to determine how piperine supplements affect inflammation in humans.

May Help Stabilize Blood Sugar Levels

Several studies suggest that BioPerine may support better glycemic control through various methods.

A study on mice shows that piperine co-administrated with a therapeutic dose of metformin significantly decreased blood glucose levels compared to metformin alone. [14]

In combination with a dose of metformin during treatment, piperine showed a remarkably more significant decrease in blood glucose than the control group. It showed a more reduction in blood glucose compared to metformin alone. [15]

Piperine can be used as a biologically active substance in co-administration with metformin, which can lower the metformin dose and its side effects. [16]

It is suggested in some animal studies that bioperine can also aid in preventing insulin resistance. This condition affects the body’s ability to use insulin to transport sugar from the bloodstream to the cells. [17]

Could Help Prevent Cancerous Cell Growth

Black pepper piperine has been reported to impede the expansion and survival of several types of cancer cells by having the effect of activating apoptotic signals and restricting cell cycle progression. [18]

Piperine, an active alkaloid, has several excellent therapeutic effects, such as antioxidants, anti-cancer, anti-inflammatory, anti-asthmatic, antispasmodic, and antifungal, [19]

Piperine is known to affect cancer cells in several ways, such as affecting redox homeostasis, preventing regeneration of cancer stem cells themselves, modification and self-renewal of endoplasmic reticulum (ER) stress, and autophagy. [20]

In particular, the therapeutic effect of piperine on breast, prostate, and colon cancer cells has been studied. [21]

In addition, one in vitro study revealed that piperine could increase therapeutic efficacy in the treatment of aggressive triple-negative breast cancer. [22]

Remember that most studies on this substance have been performed in test tubes with high and concentrated amounts of piperine. Further research is needed to understand better how bioperine could affect the progress of cancer cells in humans.

Bioperine Dosage and Safety 

Although there are no official guidelines on how much bioperine one should take, research shows that 5 to 20 mg daily are usually considered safe and have very few side effects. [23]

BioPerine manufacturers recommend 5 mg 3 times a day to get the best results. Since bioperine can reduce sugar levels, talk to your doctor before taking bioperine if you have diabetes.

Absorption of some medicines, including anticoagulants and drugs used to treat insomnia, pain, and anxiety, are affected by bioperine. If you are taking any medication, it is necessary that you take advice from your doctor before taking bioperine. 


Bioperine, an extract from black pepper, is a beneficial compound. The body easily absorbs bioperine, and it is found in several dietary supplements. 

Research shows that piperine can help increase nutrient absorption, help improve blood sugar levels, reduce inflammation, fight cancer cell growth, and improve brain function. 

Since most of the research on bioperine has been done on animals and in test tubes, further research is required to see if the compound benefits humans.

In addition, perine affect the effectiveness of some medications, so it is necessary to consult your doctor before using bioperine


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